Apesar de leyes establecidas en los años para informar a personas sobre los peligros del plomo y sus efectos venenosos, el envene- namiento por plomo . Int. J. Morphol, 2S(4), Effect of Lead Intoxication and D- Penicillamine Treatment on Hematological Indices in Rats. Efectos de Intoxicación con. conozca-los-hechos-acerca-de-la-intoxicacion-por-plomo. conozca-los-hechos- acerca-de-la-intoxicacion-por-plomo. This entry was posted on.

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In this study, subchronic lead intoxication caused a slight increase in the number of RBCs while Hb and Hct were increased.

Evaluating the genotoxic effects of workers exposed to lead using micronucleus assay, comet assay and TCR gene mutation test. The clinical picture was similar in all cases with the exception of one female patient who had encephalopathy and hepatic failure.

Efectos de Intoxicación con Plomo y Tratamiento de D-Penicilamina en índices Hematológicos en Ratas

Clinic Oral Investigation [Internet]. A olomo in hemoglobin production is probably the main cause of anemia observed in patients poisoned by lead although hemolysis caused by the effects on membrane or by inhibition of other enzymes such as 5′-pyrimidine nucleotidase may also play a key role.

At the end of 8th week, treatments were discontinued and rats drink tap water for one day.

Lead and cancer in humans: Los suelos, dando lugar a los hoy llamados “sitios contaminados”. Lead poisoning by contaminated flour: It might be due to high level of RBC production after the discontinuation of lead exposure. The purpose of the review was to characterize lead and determine its influence on the health of the population. Despite of attempts for reducing the exposure to this metal, there are still some reports of cases with severe lead toxicity Hershko, ; Roche et al.


In conclusion the present study showed that lead induced hematological changes were reversible after a period of recovery and D-penicillamine treatment did not effect in the improvement of impaired parameters affected by lead intoxication. However, long period of administration and side effects of D-P have complicated its use in the treatment of lead poisoning Shannon et al. Severe lead poisoning in the plastic industry: After recovery period, most of parameters were close to normal while there were no significant differences between recovery and treatment groups.

Effects of sub-chronic low-level lead exposure on the homeostasis of copper and zinc in rat tissues.

Lead as a carcinogen: Occupational exposure and lung cancer risk: Diciembre [citado Marzo ]; Environmental Health Perspectives [Internet]. However, we observed that these changes in PDW and MPV were reversible and they were close to normal after both of treatment and recovery periods.

The main pomo exposure source comes from lead use in industry; however, outside occupational exposure, food and water consumption is the main cause of lead exposure.

La intoxicación por plomo

Lead is a heavy metal found in its natural form in Earth’s crust, and distributed in the environment by anthropogenic or natural, fixed or mobile sources of pollutants. Platelet distribution width PDW is increased in vaso-occlusive crisis in sickle cell disease.

There are evidences about side effects of D-P, including adverse reactions, abdominal pain, depression of platelet count, leukopenia and etc.

Increased level of RBC count which was observed in lead exposed rats in our study was reported previously by other researchers lavicoli et al. Oct-Dic [citado Febrero ];25 4: Organic and inorganic lead compounds are released to the air during carbon and oil combustion.


Chronic lead poisoning- a” forgotten”cause of anemia. Efficacy and toxicity of D-penicillamine in low-level lead poisoning.

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Occupational Lead Poisoning Prevention Program.

So, discontinuation of lead exposure may result in improvement of affected parameters by improved absorption of these trace elements. Amplitude of the distribution of erythrocyte size in the differential diagnosis of microcytic anemia. The journal fully endorses the goals of updating knowledge and facilitating the acquisition of key developments in internal medicine applied to clinical practice. Efectos nocivos del plomo para la salud del hombre.

Peripheral blood and bone marrow cell status of white rats with long-term lead exposure. Blood samples were collected from their hearts and transferred to lead free polyethylene tubes containing EDTA. Nevertheless, owing to the use of artisanal procedures for wine elaboration and derivatives, its occurrence is increasing. These findings open a new window toward the understanding of the cardiovascular and cerebro vascular risks of lead exposure due to platelet dysfunction.